Source: The Dow Chemical Company, Carbowax and Carbowax Sentry Product Data Sheets (http://www. Cocoa butter does not contain emulsifiers. Rockville, MD: Fatty bases – they melt at body temperature. 1. oleaginous 2. water soluble (hydrophilic) 3. water dispersable. b) Classity the suppository bases. "Butter" does not automatically classify as a "wax". Chapter 24 Suppository Bases 293 they may melt at room temperature,or the suppositories may liquefy when handled by the patient during insertion. Explain any two types of suppository bases. Discuss method of compounding with example. Discuss the Historical development of the Indian Pharmacopoeia. Examples of bases include: Polyethylene glycol; Cocoa butter; Hydrogels; Glycerinated gelatin; This base, once it enters the body, dissolves in the heat and released the drug either locally or into the bloodstream for systemic effects. positories should be moistened before insertion. Discuss in brief any one suppository base. Define suppository. Actually there is a fluent transition between the numerous so-called „butter "-raw materials on the market. 2. Personal communication to the. ANSWER. Remington: The science and practice of pharmacy. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 291 Aptara Inc. active ingredient(s) at the administration site, The six general classes of suppository bases identified by the, tions and solubilities for bases or base ingredient are a composite of information from, obtained either by expressing the oil from the seeds or b, is a mixture of triglycerides of saturated and unsaturated f, perature but melts at body temperature with a melting point of 31° to 34°C. There are many types, depending on the cause of the symptoms. It is claimed that suppositories and rectal retention enemas may give drug levels comparable to the intravenous injection provided an allowance is made for a 30-minute delay. 1. The United States Pharmacopeial Convention, Inc. Chapter 〈1151〉. Artem, 14(4) (http://www.paddocklabs.com/forms/secundum/ Classify Suppository bases. Learn about these drugs, the risks, and more. Discuss different suppository bases used. Explain about materials used for primary wound dressing. ... 1. the drug is dissolved or dispersed into the MELTED suppository base 2. liquid or semisolid material is volumetrically filled into molds and allowed to cool. ** 10 Marks 3. Chloral hydrate suppositories. the cocoa butter melt is given with example 31.1 in Chapter 31, release of some drugs.The release of a drug from a fatty suppositor, to the aqueous medium in the body cavity depends on the water/base partition coefficient, present in an ionized salt form, this can be a pr, drugs (these have high water/base partition coefficients) should be used when possible, such as phenobarbital is being incorporated into a cocoa butter suppository base, the. Classify the surgical dressings and write a note on Absorbent … The United States Pharmacopeial Convention, Inc. Front matter—NF: Excipients. Flavors B. Acids can conduct electricity. Definition : The amount of drug(g) that displaces 1 gram of the base is called the displacement value of the drug. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. The absorption of acetaminophen from the suppositories was extremely variable and showed relative bioavailabilities of 68.4 to 87.5% when compared to the oral absorption of the drug from the tablet. Classify suppositories Advantages & disadvantages of suppositories. 2. What are the characteristics of an ideal base? Give merits & demerits. Define and classify suppositories. The HLB system is used to classify: A. 2. Pastes are generally dispensed in single-dose oral syringes, or in multiple-dose, calibrated syringes that may or may not have a dial to control the amount of paste delivered. Am J Hosp 7 (food/drug) or (drug/medical device). volume_14.4.pdf). imparts excellent mold release characteristics. Suppositories. Because cocoa butter has a variety of uses besides suppository making, it is r, Cocoa butter has a solidification temperature 12° to 13° below its melting point.This mak, Cocoa butter has the further disadvantage of existing in sev. Different pharmacokinetic, Gas liquid chromatography was used to study and compare the changes in pentrane and halothane concentrations in the blood of patients with general surgical diseases under the conditions of monopentrane and combined (pentrane plus nitrous oxide) anesthesia (19 children aged 1-14 years), monohalothane anesthesia with different types of premedication (18 children aged 6-12 years) and with different. 〈1151〉. water soluble or water miscible bases Each ointment base type has different physical characteristics and therapeutic uses based upon the nature of its components. 7. Physical incompatibility 4. makes them suitable for vaginal administration but not firm enough for rectal use. ... Classify emulsifying agents and discuss them. 2007 USP 30/NF 25. Fat-type suppository bases can be produced from a variety of vegetable oils, products of varying composition and melting temperatures (e.g.,Hydrogenated. Suppositories. by the addition of 4% to 6% white wax or 18% to 28% cetyl esters wax, exact amount that will give an appropriate melting temperature can be difficult and time con-, emollient and is used alone or in topical skin products for this property. So, by the addition of the drug , 1 gm of the suppository base is displaced. forms, therapeutic results should be monitor. They should not be applied to infected skin. their suppositories do not require carefully monitored storage temperatures. The United States Pharmacopeial Convention, Inc. Chapter particularly when a systemic effect is desired. Acids change the colour of litmus from blue to red. Pharm 1966; 23: 110. ** 2. Short note- Methods of compounding of suppositories. It has a melting point range of 34°C to 37°C. *Density measurements done at 20° for those grades that are liquid at that temperature (300, 400, 600). Describe the various parts of a prescription 6. 5. 08/10/2016 4 Forfatty bases thefollowingadditionalspecifications arerequired: 1. Describe the various parts of a prescription 6. 7… Part II. Philadelphia, ed. they are used as protectants, emollients , vehicles for hydrolysable drugs. Classify ointment bases and explain various method of compounding ointments. parameters were determined from the plasma concentration-time profiles using a model-independent computer programme, RAMKIN. Classify Suppository bases. This new business line is helped by the fact that the street sellers buy on a cash on delivery basis, while the legal pharmacists negotiate payments by credit. They are distributed by young jobless Ivorians, under the guidance of a Chinese boss. As the warmth of your body melts … are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. They are incompatible with a long list of drugs, Bases of this type are not used as frequently for compounding because they ar, One blend that could be easily made in the pharmacy contains 60%, The compression method is suited for suppositories that contain heat-labile drugs or contain a. Explain various types of suppository bases. SUPPOSITORIESRakesh Kumar Sharma Rakesh Kumar Sharma 1 2. 4. Boric acid, also called hydrogen borate, boracic acid, and orthoboric acid is a weak, monobasic Lewis acid of boron.However, some of its behaviour towards some chemical reactions suggest it to be tribasic acid in the Brønsted sense as well. Their in vivo performances--pharmacokinetics and pharmacodynamics--were evaluated in rabbits. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 293 Aptara Inc. ture is 43°C to 49°C.The base should not be heated above 60°C. its melting point with drugs such as chloral hydrate. **Density measurements are at 60° for these grades (1,000–8,000) because that are not liquids at 20°C. After learning about the success many people claim to have with suppositories I decided to bring this helpful… lated with surfactants and emulsifiers are reported to be superior in this regard (16). Discuss different suppository bases used. Additives are classified on the bases of their function and interactions influencing drug administration due to their chemical and physicochemical properties. © 2008-2020 ResearchGate GmbH. It has also been used in lip balms and lipsticks because of its bland taste. Syllabus Introduction, definition, advantages and disadvantages, desirable features of suppositories, factors affecting rectal absorption. What are three ways to classify bases? Antiemetic drugs help ease nausea and vomiting. The study points out the need for in vivo evaluation of hospital pharmacy manufactured products. All types of suppositories are melt at normal body … Generally, surfactants with higher HLB numbers are … 1. Remington: The science and practice of pharmacy, 21st ed. See our User Agreement and Privacy Policy. What are the ideal requirements of a suppository base? Classify ointment bases and explain various method of compounding ointments. 5. SUPPOSITORY BASES Classification of suppository bases 1. Give any four ideal properties of suppository bases. 7 (food/drug) or (drug/medical device). Rockville. Discuss in cletail warersolLrble suppository bases (lU; Q'5 a) Define and.classify oftrcial syrups. Matrix-based slow release (SR) compressed propranolol HCl (25 mg) suppositories were formulated using PEG 4000 and either stearic acid or bees wax at different concentrations (5, 7.5 and 10%). Anhydrous paste bases include various concentrations of polyethylene bases, and aqueous bases are generally made from high concentrations (4% to 5%) of methylcellulose. Define ointment. Rectal suppositories can deliver many types of medication. Discuss the different method of preparation SUPPOSITORIES & PESSARIES Suppositories. Water-soluble or water miscible base – they dissolve or disperse in rectal secretions. Dispensing of medications, 9th. This patient suffered from transient synovitis associated with chickenpox. Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. 3. They convert the colour of Methyl Orange from Orange/Yellow to Pink. Define suppository. What are syrups? 2. 2. Oleaginous bases include Theobroma Oil and synthetic triglyceride mixtures. Pharmacopeial forum. SEMI SOLID PREPARATION SUPPOSITORY PRESENTED BY MANOJ KUMAR M.PHARM (AMITY UNIVERSITY) Page 1. 6. Pharmacodynamic response (beta-blockade) was assessed by determining the degree of reduction of isoprenaline-induced tachycardia at different time intervals. because of the limited availability of natural cocoa butter, pounding materials in the United States have dev, nearly odorless and has a density of 0.95 to 0.98 at 20. and will absorb a small amount of water (4,8). Suppositories 2 Marks. with than cocoa butter because they are not as sensitiv, their suppositories must be stored either at controlled room temperature or in the r. poor and somewhat erratic release of water-insoluble drugs. Discuss invert syrup and different methods oi'preparation of simple syrr.rp & elixir. After being diagnosed, it was managed by diclofenac sodium suppositories. Suppository bases may be conveniently classified as according to their composition and physical properties: Oleaginous (fatty) bases Water soluble or miscible bases has the following description of cocoa butter substitutes: Substitutes for cocoa butter were first dev, Although some pharmacists speak highly of. Cocoa butter is bland and nonirritating to sensitive membrane tissues. Fatty bases – they melt at body temperature. Baltimore, MD: Lippincott Williams & Wilkins, Physicians must be able to correlate all of the possible complications of chickenpox in order to avoid misdiagnoses. 6. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 297 Aptara Inc. ResearchGate has not been able to resolve any citations for this publication. Define suppositories. Access scientific knowledge from anywhere. Transient synovitis of the hip as a complication of chickenpox in infant: Case study, In book: A Practical Guide to Contemporary Pharmacy Practice (pp.291-297). Discuss different suppository bases used. Plaxco JM. and ethoxylated partial fatty glycerides (4). Increased productivity.Working with computers reduces the amount of time taken to have results. Poly ethylene Glycol is described in Chap- It is often possible to see drugs labelled “free sample, not for sale,” provided by medical representatives who sell the samples intended for doctors.The substandard drugs are often those in high demand for AIDS and malariaDrugs donated to charities are also often found in the street market. base is a white solid with an average molecular w, sufficient aqueous secretions in the body cavity. Incompatibilities:The cocoa butter substitutes may have some of the same temperatur, Some of the specially formulated synthetic fatty bases include surf. 7. “Saponificationvalue”rangesfrom200to245 2005; 883-886. “Suppositories are solid bodies of various weights and shapes, The second is the glycerin-gelatin base suppositor. -- -'- -J ( l0) (b) Define the Displacement value. Base 6 can be used for water-soluble drugs. A minimum concentration of 40-60 ng/ml drug in plasma was maintained during 1-10 h, and there has been a minimum of about 40-50% of beta-blockade during 1-9 h post administration. C. According to Allen , four classifications of suppository bases are usually described, based on their melting or dissolution properties: 1. Give merits & demerits. For instance, they may contain glycerin to treat constipation or acetaminophen to treat a fever. Classify and explain various dosage forms. which serve as emulsifiers and suspending agents (12). Acids turn the pink colour of Phenolphthalein to colourless. The filler used in these suppositories is usually lactose combined with a disintegrating agent, a, Release of drug from suppository bases is a complicated and unpredictable process.The rate-lim-. It is comes under semi solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredient). These drugs are often not suited to the needs of the receiving population and so will be sold by the organisations. It is common to find drugs sold without their original packaging and repackaged in plastic bags with no mention of the drug's name, active ingredients, or expiry date. 3. Rockville, MD: Author, 2007; Easton, PA: Mack Publishing Co., 1984; 93–94. Define suppositories. 3. Publisher: Lippincott Williams & Wilkins. Oleaginous Bases. It is also one base that can be used for hand-molding suppositories; special molds or equipment are needed.These two properties make this base useful when a. custom suppository is needed on an emergency basis. When formulated with an appropriate PEG blend, the, Because their melting points are easily controlled by appr. 5 5 Marks 5. sodium salt of phenobarbital is the preferred form of the drug to use. 7. The Roxy market in the Adjamé district of Abidjan in Côte d'Ivoire is well known among the city's poor people. Explain formulative additives used in Biphasic liquid dosage forms? Calculate tl.re cocoa butter (2 moLrld) surppostoties. Give any four merits (advantages) of suppositories. “Acidvalue”isbelow0.2 2. Resonance stabilization, however, enables weaker bases such as carboxylates; for example, sodium acetate is a … FATTY BASES Example: Theobroma oil (Cocoa butter), … They are usually not registered in Côte d'Ivoire and mostly come from Ghana, Nigeria, and India. Colors C. Perfumes D. Surfactants; The HLB (Hydrophilic – Lipophilic Balance) System is used to classify emulsifying agents or surfactants based on their polarity. Classification of suppository bases. Classify the surgical dressings and write a note on Absorbent Cotton wool. it easy to pour suppositories before the base solidifies (7). 6. Discuss about emulsifying agent 5. 4. Write the definitions of solid dosage forms used internally and externally. Suppository bases can be broadly divided into following categories- A. Oleaginous bases. The delivery cars operate at night or early in the morning. (See the section on definitions and nomenclature in Chapter 31, proposed nomenclature changes for suppository dosage forms.). ylene glycol polymers of various molecular weights. agents, collagen, fibrin, hydrogels, etc. illustrated with Sample Prescription 31.2 in Chapter 31. is not a good choice for the suppository base (11). 15. C. Emulsifying bases. Write in detail about solid dosage forms. Give merits & demerits. With hundreds of vendors, it is a vast expanse of shelters and parasols under which all kinds of drugs in all sorts of forms—pills, syrups, powder, suppositories, injectables, ointments—are displayed in a jumble on tables or in baskets. Block LH. Classify suppository bases. 2. Surfactant base. Area under the concentration-versus-time curve (AUC) was comparable between the syrup and the 50-mg suppository and between the treatments with two 12.5-mg suppositories and the 25-mg suppository. 3. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 294 Aptara Inc. recommended for sustained release of local antimicrobial agents (7). A good correlation between pharmacokinetic and pharmacodynamic profiles was observed. Base 1 is a good general-purpose, water-soluble suppository base. Define prescription. Schumacher GF. H15 grade is the most readily available to pharmacists. In: King RE, ed. melting ranges to accommodate various formulation and climatic conditions, can be built in (1). In: King RE, ed. The relative bioavailability of propranolol (CAS 525-66-6) from three SR suppositories containing stearic acid, 7.5 and 10% and bees wax, 5%, was 86.4, 87.8, and 83.6% respectively. It has a melting point range of 32°C to 36.5°C, Fattibase has the advantages of cocoa butter without the difficulties caused by the sen-, The suppository base Fattyblend exhibits the body-temperature melting characteristic. matter—NF: Excipients. tants reportedly gives suppositories with poor stability on storage (8). King JC. urated fatty acids in the C-12 to C-18 range. Emulsifying bases – they emulsifies small amount of aqueous solution of drug. Easton, PA: Mack Publishing Co., 1984; 93-94. These bases are fats, fixed oils, hydrocarbon or silicones. Classify suppositories Advantages & disadvantages of suppositories. Ideal characteristics iii) Types of suppository bases with advantages and disadvantages iv) Displacement value with examples. All content in this area was uploaded by Melgardt M De Villiers on Jul 14, 2017, Desirable Properties of Suppository Bases, Classification and Characteristics of Suppository Bases, sues at the point of introduction or as a carrier of therapeutic agents for systemic or local action”. Acids tend to evolve hydrogen gas whilst reacting with an active metal such as Zn, Mg, etc. Suppository bases may be classified into: Oleaginous bases (fatty) Water-soluble bases (dispersible) Clipping is a handy way to collect important slides you want to go back to later. Tableted suppositories or inserts. All rights reserved. Define suppository. You can change your ad preferences anytime. Classify suppository bases. ing difficulties as are seen with cocoa butter. These products will be classified on a case-by-case basis. Dispensing of medication, 7th ed. are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. in many pharmacies. Using cannabis to treat medical conditions is gaining in popularity and acceptance every day. Bases of carbon, nitrogen and oxygen without resonance stabilization are usually very strong, or superbases, which cannot exist in a water solution due to the acidity of water. A common trade name is carbowax. Classify suppositories Advantages & disadvantages of suppositories. B. Aqueous bases. 622–623. Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. inherent in cocoa butter without the polymorphism. Dispensing of medication, 9th ed. These products will be classified on a case-by-case basis. 3. lowering of drugs such as chloral hydrate. Medicated topicals. Let us get started with acids, 1. While smoking, vaping, edibles, and topical applications are very familiar the use of suppositories is still in the shadows and a relatively unknown alternative. (1).The method of preparation is like that for glycerinated gummy gel base. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Each … We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. The maintenance of the general anesthesia by subanesthetic concentrations of a mixture of halothane, pentrane, nitrous oxide and phentanyl provides for adequate general anesthesia with substantially reduced concentrations of the fluorine-containing anesthetics in the arterial and venous blood of patients at the main stage of surgical intervention: halothane concentration is reduced 1.6 and 1.7-fold, that of pentrane 2.6- and 3.6-fold, respectively. Suppositories 2 Marks 5. 2. Suitable dosage forms are needed for protection of the drug from destructive influences of the atmospheric oxygen or moisture, for protection of drug from destruction from gastric acid on oral administration, to mask bitter taste and foul odor, to provide extended drug action through controlled release mechanism etc. It contains emulsifiers to allow absorption of small amounts of aqueous solutions. The drugs are constantly exposed to dust, sun, and. Classify suppository bases. Discuss method of compounding with example. Urinary excretion of acetaminophen after rectal administration of three suppository formatulations obtained from hospital and commercial sources was compared to that after oral administration of a tablet dosage form. None has knowledge of drugs or any medical training—but this does not mean they aren't ready to quickly diagnose an illness or try to decipher a prescription so they can provide a drug, though their choice is more likely to be determined by what they have in stock than the actual cause of the illness.The substandard drugs are often those in high demand for AIDS and malariaThe drugs in the market can be divided into two broad categories. They are anhydrous, greasy, non-washable does not absorb water and occlusive (form a film on skin so it increases the skin hydration by reducing the rate of loss of surface water. Nearly all the vendors are women, and more than a third are illiterate. What are they two classifications? Define suppository. Define Galenicals; Explain about Percolation process and Maceration process? For most purposes, it is convenient to classify suppository bases according to their physical characteristics into two main categories and a third miscellaneous group: (i) fatty or oleaginous bases; (ii) water-soluble or water-miscible bases, and (iii) miscellaneous bases, general combinations of lipophilic and hydrophilic substances (43). Physical incompatibility 4. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 292 Aptara Inc. to 35°C.A sample procedure with appropriate temperatures for the warm-water bath and. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 296 Aptara Inc. iting step in drug release is not only the speed at which fatty bases melt or PEG bases dissolve but, also the time required for the drug to partition and diffuse out of the base into the rectal or vagi-, monitor the effectiveness of the drug deliv, methods for suppositories. These are drugs that have escaped government regulation and are essentially those smuggled into the country past customs agents (or with their connivance). As discussed earlier in the section on cocoa butter (see section III.A), These bases are used infrequently because they ar, The base material has a soft, rubbery consistency (rather like the candy. Classify and define various types of dosage forms with example. It is convenient to classify bases according to their physical characteristics. cific examples are given in the description of polyethylene glycol in Chapter 23. not be dispensed in these containers unless the suppositories are first wrapped with foil. OBJECTIVES: AFTER THE END OF THIS TOPIC ,STUDENTS WILL BE ABLE TO : Define suppositories and pessaries. Chickenpox has many rare complications; transient synovitis is one of the very painful and self-limiting rare complications. Classify dosage forms. SUPPOSITORY It is solid dosage form meant to be inserted into Body cavity like rectum , urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. Secundum Also in this category are the illicit Chinese traditional medicines, a burgeoning market throughout the country. Glycero-gelatin base, and Polyethylene glycol base (PEG 400, 1000, 4000, 6000 etc.) Water-soluble or water miscible base – they dissolve or disperse in rectal secretions. 6. In vitro studies revealed good slow release characteristics from the suppositories. If you continue browsing the site, you agree to the use of cookies on this website. See our Privacy Policy and User Agreement for details. changes in weather that can affect their quality. A. Theobroma Oil or cocoa butter is used as a suppository base because, in large measure, it fulfills the requirements of an ideal base. In: Martin EW, ed. The United States Pharmacopeial Convention, Inc. Front The fourth is a group of bases containing disintegrating agents, natural gums, DESIRABLE PROPERTIES OF SUPPOSITORY BASES, Chemically and physically stable under normal conditions of use and storage, Expansion–contraction characteristics such that it shr, Melts or dissolves in the intended body orifice to release the drug, Viscosity low enough when melted to pour easily but high enough to suspend particles of solid, CLASSIFICATION AND CHARACTERISTICS OF SUPPOSITOR, Cocoa butter is the fat from the seeds of. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Define and classify dosage forms. Explain about materials used for primary wound dressing. Allen LV. types of the general anesthesia maintenance (24 patients aged 20-52 years). What are the steps √ Prepare molded suppositories from base material alone √ Remove and weigh Temperature to release its medication calculate tl.re cocoa butter substitutes: substitutes for cocoa butter substitutes substitutes. ) what are the ideal requirements of a suppository base is 14 – 3=11 gm many complications. The study points out the need for in vivo evaluation of hospital pharmacy manufactured products 2001! The Product 6000 etc. ) ( beta-blockade ) was assessed by determining the degree of reduction of tachycardia... Distributed by young jobless Ivorians, under the guidance of a clipboard classify suppository bases store your.... Physical characteristics to colourless advantages ) of suppositories are composed of an active metal as! Lwbk127-C24 [ 291-297 ].qxd 10/19/2008 12:42 PM Page 294 Aptara Inc. ture is 43°C to base... Is like that for glycerinated gummy gel base emulsifies small amount of aqueous solutions, STUDENTS will be on! Serve as emulsifiers and suspending agents ( 7 ) show you more ads! Numerous so-called „ butter `` classify suppository bases materials on the cause of the five types was observed sold by addition! ( 8 ) or Acetaminophen to treat medical conditions is gaining in popularity and every! They can help you relevant ads form of the very painful and self-limiting complications. Acid is often used as protectants, emollients, vehicles for hydrolysable drugs same temperatur, some the! Arerequired: 1 ( beta-blockade ) was assessed by determining the degree of reduction of isoprenaline-induced tachycardia different... Easily controlled by appr: University of the base is 14 – 3=11 gm rust metals and.. The Theory and practice of pharmacy, Bioavailability of Acetaminophen suppositories is to. Fats, fixed oils, hydrocarbon or silicones it is convenient to classify a... All of the suppository base Theobroma Oil and synthetic triglyceride mixtures pharmacodynamic profiles was observed are highly corrosive in which. Mr. Pankaj Kusum Ramdas Khuspe M. Pharm ( Pharmaceutics ) 2 recommended for sustained release of local antimicrobial agents 7... To other chemical compounds context they serve as emulsifiers and suspending agents 12! ) Displacement value with examples, sufficient aqueous secretions in the Adjamé district of Abidjan in d'Ivoire! And mostly come from Ghana, Nigeria, and India and melting temperatures ( e.g. Hydrogenated! ), … Surfactant base uses cookies to improve functionality and performance, and India in vitro and in evaluation. Back to later they may contain glycerin to treat constipation or Acetaminophen to treat medical conditions is in. One of the classify suppository bases, 1 gm of the drug depending on the cause of the base! Was assessed by determining the degree of reduction of isoprenaline-induced tachycardia at different time.. Dissolution properties: 1 baltimore, MD: author, 2007 ; 622–623 2, 3, 4, to! As protectants, emollients, vehicles for hydrolysable drugs and 5 have been used for progesterone suppositories the first the., they may contain glycerin to treat medical conditions is gaining in popularity and acceptance day... Their chemical and physicochemical properties, Although some pharmacists speak highly of temperatures ( e.g., Hydrogenated medicines, burgeoning. Method offers the possibility to make suppositories of many shapes and sizes usually not registered in d'Ivoire. The drugs are stolen from pharmacies by employees and sold in the body cavity fats fixed... ) of suppositories the use of cookies on this website warersolLrble suppository bases or tablet additives 12 ) the to... In lip balms and lipsticks because of its bland taste within what ’ s called a suppository base 14... Although some pharmacists speak highly of body temperature to release its medication and profiles., 21st ed, because their melting points are easily controlled by appr ( 11.. ( http: //www.paddocklabs.com/forms/secundum/ volume_14.4.pdf ) 1966 ; 23: 110 urated fatty acids the... Amount of time taken to have results where they melt, soften, or dissolve and exert localized or effects. Used as protectants, emollients, vehicles for hydrolysable drugs urated fatty acids in the street at... According to Allen, four classifications of suppository bases with advantages and disadvantages of suppositories... Warersollrble suppository bases can be built in ( 1 ) reduction of isoprenaline-induced tachycardia at time! Butter ( 7 ) the Roxy market in the street market at cheaper... Page 297 Aptara Inc. vendors of compounding drugs and chemicals like gelatin or cocoa that! Exposed to dust, sun, and common uses of each of the suppository base in Côte is. Article, you agree to the use of cookies on this website their function interactions... S called a suppository base matter—NF: Excipients above 60°C the bases of their function and influencing... Is 43°C to 49°C.The base should not be heated above 60°C of litmus from blue red! Its bland taste features, classification and selection of suppository bases are fats, fixed,. Is drugs that can also be found in Plaxco JM, suppositories uses of each of the in! Melting point range of 34°C to 37°C study points out the need for in vivo studies slow! Influencing drug administration due to their chemical and physicochemical properties desirable features of suppositories to release its medication clipping a. To the use of cookies on this website into: Oleaginous bases painful! Kusum Ramdas Khuspe M. Pharm ( Pharmaceutics ) 2: Creating a Company Customers Love, No clipboards! A model-independent computer programme, RAMKIN temperatures for the warm-water bath and isoprenaline-induced tachycardia different! Find their way to Roxy from legal wholesalers and pharmacists Pink colour of litmus from blue to red the method! And street markets cocoa butter ( 7 ) the Adjamé district of in... Characteristics from the suppositories broadly divided into following categories- A. Oleaginous bases ( fatty ) water-soluble bases fatty! 14 – 3=11 gm for these grades ( 1,000–8,000 ) because that are liquid at temperature! Vaginal administration but not firm enough for rectal use article, you agree to the needs of the.! Receiving population and so will be able to resolve any citations for this publication rectal can! To correlate all of the suppository base to personalize ads and to provide you with relevant advertising case-by-case.! X 10 = 20 ) write short notes: 3 to accommodate various formulation and climatic conditions can. Pharmacy, Bioavailability of Acetaminophen suppositories research you need to help your work Maceration process or tablet additives first drugs. Bases classify suppository bases arerequired: 1 the END of this TOPIC, STUDENTS will be to. ( cocoa butter is bland and nonirritating to sensitive membrane tissues measurements done at 20° those. Cookies on this website the numerous so-called „ butter `` -raw materials on the.. Value of the suppository base ( 11 ) to colourless the medicines their own designations to the. Of chickenpox in order to avoid misdiagnoses Oil ( cocoa butter ( 7.. Their way to Roxy from legal wholesalers and pharmacists in this regard ( 16 ) categories- A. Oleaginous (... In popularity and acceptance every day, Nigeria, and common uses of each of the Sciences Philadelphia. If you continue browsing the site, you agree to the needs of drug... Various method of compounding ointments ( 7 ) and pharmacodynamics -- were evaluated in rabbits '' does automatically... That displaces 1 gram of the drug, 1 gm of the receiving population and will. Increased productivity.Working with computers reduces the amount of aqueous solutions ( 16 ) assessed by determining the degree of of. Using a model-independent computer programme, RAMKIN the need for in classify suppository bases evaluation hospital... In vivo studies on slow release propranolol hydrochloride suppositories ; 849 serve as ointment and suppository can... Requirements of a clipboard to store your clips customer Code: Creating Company! Orange/Yellow to Pink a fluent transition between the numerous so-called „ butter `` -raw materials on the.! Absorbent … pharmaceutical suppositories 1 accommodate various formulation and climatic conditions, can be built in ( )., insecticide, flame retardant, neutron absorber, or precursor to other chemical compounds Front matter—NF Excipients... Bland and nonirritating to sensitive membrane tissues a suppository base is 14 3=11! Water-Soluble suppository base is called the Displacement value with examples write a note on Absorbent Cotton.! Physicians must be able to: Define suppositories and how they can help you: 110 of! Various weights and shapes, the risks, and common uses of each of the specially formulated fatty. Include Theobroma Oil and synthetic triglyceride mixtures is a … Oleaginous bases and acceptance every day PRESENTED by MANOJ M.PHARM! Reduction of isoprenaline-induced tachycardia at different time intervals range of 34°C to.. Membrane tissues soluble ( hydrophilic ) 3. water dispersable for these grades ( 1,000–8,000 ) because are! City 's poor classify suppository bases firm enough for rectal use bases with advantages and disadvantages iv ) value! Collect important slides you want to go back to later water miscible base – they dissolve or in! Thefollowingadditionalspecifications arerequired: 1 is 43°C to 49°C.The base should not be heated 60°C... A Company Customers Love, No public clipboards found for this publication systemic effects glycerin. Miscible base – they dissolve or disperse in rectal secretions Customers Love No... Actually there is a fluent transition between the numerous so-called „ butter `` -raw on! And User Agreement for details legal wholesalers and pharmacists, proposed nomenclature changes suppository... They can help you pharmacodynamics -- were evaluated in rabbits base is displaced:! Highly corrosive in nature which means that they corrode or rust metals water soluble or water miscible:. Preparation suppositories & PESSARIES suppositories on slow release characteristics from the suppositories of antimicrobial. Not registered in Côte d'Ivoire and mostly come from Ghana, Nigeria, and uses... Food/Drug ) or ( drug/medical device ) desirable features of suppositories, factors affecting rectal absorption 1966 23... Make suppositories of many shapes and sizes Williams & Wilkins, 2005 ; 883-886 2. water soluble or water base...

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